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QUANTITATIVE ASSESSMENT OF RANGE FLUCTUATIONS IN CHARGED PARTICLE LUNG IRRADIATION
https://repo.qst.go.jp/records/45053
https://repo.qst.go.jp/records/4505390b1b198-7425-471b-8eff-af8af1ca681c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-17 | |||||
| タイトル | ||||||
| タイトル | QUANTITATIVE ASSESSMENT OF RANGE FLUCTUATIONS IN CHARGED PARTICLE LUNG IRRADIATION | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mori, Shinichiro
× Mori, Shinichiro× Chen, George× et.al× 森 慎一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Water equivalent path length (WEL) variations due to respiration can change the range of a charged particle beam and result in beam overshoot to critical organs or beam undershoot to tumor.We have studied range fluctuations by analyzing four-dimensional computed tomography data and quantitatively assessing potential beam overshoot. Methods and Materials: The maximal intensity volume is calculated by combining the gross tumor volume contours at each respiratory phase in the four-dimensional computed tomography study. The first target volume calculates the maximal intensity volume for the entire respiratory cycle (internal target volume [ITV]-radiotherapy [RT]), and the second target volume is the maximal intensity volume corresponding to gated RT (gated-RT, ~30% phase window around exhalation). A compensator at each respiratory phase is calculated. Two "composite" compensators for ITV-RT and gated-RT are then designed by selecting the minimal compensator depth at the respective respiratory phase. These compensators are then applied to the four-dimensional computed tomography data to estimate beam penetration. Analysis metrics include range fluctuation and overshoot volume, both as a function of gantry angle. We compared WEL fluctuations observed in treating the ITV-RT versus gated-RT in 11 lung patients. Results: The WEL fluctuations were <21.8 mm-WEL and 9.5 mm-WEL for ITV-RTand gated-RT, respectively for all patients. Gated-RTreduced the beam overshoot volume by approximately a factor of four compared with ITVRT. Such range fluctuations can affect the efficacy of treatment and result in an excessive dose to a distal critical organ. Conclusion: Time varying range fluctuation analysis provides information useful for determining appropriate patient-specific treatment parameters in charged particle RT. This analysis can also be useful for optimizing planning and delivery. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 70, 号 1, p. 253-261, 発行日 2008-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2007.08.049 | |||||
