{"created":"2023-05-15T14:34:50.899035+00:00","id":45053,"links":{},"metadata":{"_buckets":{"deposit":"522136b9-d066-4c8b-a347-6be7208de119"},"_deposit":{"created_by":1,"id":"45053","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45053"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045053","sets":["1"]},"author_link":["447400","447402","447401","447403"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"261","bibliographicPageStart":"253","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Water equivalent path length (WEL) variations due to respiration can change the range of a charged particle beam and result in beam overshoot to critical organs or beam undershoot to tumor.We have studied range fluctuations by analyzing four-dimensional computed tomography data and quantitatively assessing potential beam overshoot.\nMethods and Materials: The maximal intensity volume is calculated by combining the gross tumor volume contours at each respiratory phase in the four-dimensional computed tomography study. The first target volume calculates the maximal intensity volume for the entire respiratory cycle (internal target volume [ITV]-radiotherapy\n[RT]), and the second target volume is the maximal intensity volume corresponding to gated RT (gated-RT, ~30% phase window around exhalation). A compensator at each respiratory phase is calculated. Two \"composite\" compensators for ITV-RT and gated-RT are then designed by selecting the minimal compensator depth at the respective\nrespiratory phase. These compensators are then applied to the four-dimensional computed tomography data to estimate beam penetration. Analysis metrics include range fluctuation and overshoot volume, both as a function of gantry angle. We compared WEL fluctuations observed in treating the ITV-RT versus gated-RT in 11 lung patients.\nResults: The WEL fluctuations were <21.8 mm-WEL and 9.5 mm-WEL for ITV-RTand gated-RT, respectively for all patients. Gated-RTreduced the beam overshoot volume by approximately a factor of four compared with ITVRT. Such range fluctuations can affect the efficacy of treatment and result in an excessive dose to a distal critical organ.\nConclusion: Time varying range fluctuation analysis provides information useful for determining appropriate patient-specific treatment parameters in charged particle RT. This analysis can also be useful for optimizing planning and delivery.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijrobp.2007.08.049","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"447400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chen, George"}],"nameIdentifiers":[{"nameIdentifier":"447401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"447402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447403","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"QUANTITATIVE ASSESSMENT OF RANGE FLUCTUATIONS IN CHARGED PARTICLE LUNG IRRADIATION","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"QUANTITATIVE ASSESSMENT OF RANGE FLUCTUATIONS IN CHARGED PARTICLE LUNG IRRADIATION"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-17"},"publish_date":"2007-12-17","publish_status":"0","recid":"45053","relation_version_is_last":true,"title":["QUANTITATIVE ASSESSMENT OF RANGE FLUCTUATIONS IN CHARGED PARTICLE LUNG IRRADIATION"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:08:14.832592+00:00"}