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Irradiation of DNA loaded with platinum containing molecules by fast atomic ions C6+ and Fe26+
https://repo.qst.go.jp/records/45050
https://repo.qst.go.jp/records/450503f43e011-7d6b-42f6-87fa-24ac8c1fbaf7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-17 | |||||
| タイトル | ||||||
| タイトル | Irradiation of DNA loaded with platinum containing molecules by fast atomic ions C6+ and Fe26+ | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Usami, Noriko
× Usami, Noriko× Kobayashi, Katsumi× Furusawa, Yoshiya× LACOMBE, Sandrine× Le, Sech Claude× et.al× 宇佐美 徳子× 小林 克己× 古澤 佳也× ＬＡＣＯＭＢＥ Ｓａｎｄｒｉｎｅ× ルシェッ クロード |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: In order to study the role of the Linear Energy Transfer (LET) of fast atomic ions in platinum-DNA complexes induction of breaks, DNA Plasmids were irradiated by C6? and Fe26? ions. Material and methods: DNA Plasmids (pBR322) loaded with different amounts of platinum contained in a terpyridineplatinum molecule (PtTC) were irradiated by C6? ions and Fe26? ions. The LET values ranged between 13.4 keV/mm and 550 keV/mm. In some experiments, dimethyl sulfoxide (DMSO) was added. Results: In all experiments, a significant increase in DNA strand breaks was observed when platinum was present. The yield of breaks induced per Gray decreased when the LET increased. The yield of single and double strand breaks per plasmid per track increased with the LET, indicating that the number of DNA breaks per Gray was related to the number of tracks through the medium. Conclusions: These findings show that more DNA breaks are induced by atomic ions when platinum is present. This effect increases for low LET heavy atoms. As DSB induction may induce cell death, these results could open new perspectives with the association of hadrontherapy and chemotherapy. Thus the therapeutic index might be improved by loading the tumour with platinum salts. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 83, 号 9, p. 569-576, 発行日 2007-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553000701447130 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1080/09553000701447130 | |||||
| 関連名称 | http://dx.doi.org/10.1080/09553000701447130 | |||||
