@article{oai:repo.qst.go.jp:00045050,
 author = {Usami, Noriko and Kobayashi, Katsumi and Furusawa, Yoshiya and LACOMBE, Sandrine and Le, Sech Claude and et.al and 宇佐美 徳子 and 小林 克己 and 古澤 佳也 and ＬＡＣＯＭＢＥ Ｓａｎｄｒｉｎｅ and ルシェッ クロード},
 issue = {9},
 journal = {International Journal of Radiation Biology},
 month = {Jan},
 note = {Purpose: In order to study the role of the Linear Energy Transfer (LET) of fast atomic ions in platinum-DNA complexes
induction of breaks, DNA Plasmids were irradiated by C6? and Fe26? ions.
Material and methods: DNA Plasmids (pBR322) loaded with different amounts of platinum contained in a terpyridineplatinum molecule (PtTC) were irradiated by C6? ions and Fe26? ions. The LET values ranged between 13.4 keV/mm and 550 keV/mm. In some experiments, dimethyl sulfoxide (DMSO) was added.
Results: In all experiments, a significant increase in DNA strand breaks was observed when platinum was present. The yield of breaks induced per Gray decreased when the LET increased. The yield of single and double strand breaks per plasmid per track increased with the LET, indicating that the number of DNA breaks per Gray was related to the number of tracks through the medium.
Conclusions: These findings show that more DNA breaks are induced by atomic ions when platinum is present. This effect increases for low LET heavy atoms. As DSB induction may induce cell death, these results could open new perspectives with the association of hadrontherapy and chemotherapy. Thus the therapeutic index might be improved by loading the tumour with platinum salts.},
 pages = {569--576},
 title = {Irradiation of DNA loaded with platinum containing molecules by fast atomic ions C6+ and Fe26+},
 volume = {83},
 year = {2007}
}