WEKO3
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To clarify\nthe effects of heavy-ion beams on hematopoietic stem/progenitor cells, the\neffects of carbon-ion beams on megakaryocytopoiesis and thrombopoiesis in CD34(+)\ncells derived from human placental and umbilical cord blood were investigated.\nThe cells were exposed to carbon-ion beams (LET = 50 keV/microm) and then were\ntreated with thrombopoietin (TPO) alone or TPO plus other cytokines.\nMegakaryocytic progenitor cells, such as megakaryocyte colony-forming units\n(CFU-Meg), were far more sensitive to carbon-ion beams than to X rays, and no\nrestoration of carbon-ion beam-irradiated CFU-Meg by treatment with any cytokine \ncombination was observed. However, total cell expansion in liquid culture was not\ndifferent after either carbon-ion beam or X irradiation of CD34(+) cells. The\nactivation of gamma-H2AX, a marker of DNA double strand-breaks (DSBs), was\npromoted by the cytokine treatment in X-irradiated CD34(+) cells but not in\ncarbon-ion-irradiated cells. These results showed that carbon-ion beams inflicted\nsevere damage on megakaryocytopoiesis and thrombopoiesis and that a better\ncombination of cytokines and other agents may be needed to stimulate the recovery\nof hematopoietic cells and repair this damage.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0033-7587", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahashi, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "447348", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Monzen, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "447349", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi-Kasai, Kiyomi"}], "nameIdentifiers": [{"nameIdentifier": "447350", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abe, Yoshinao"}], "nameIdentifiers": [{"nameIdentifier": "447351", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kashiwakura, Ikuo"}], "nameIdentifiers": [{"nameIdentifier": "447352", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋 賢次", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "447353", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "門前 暁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "447354", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笠井 清美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "447355", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "阿部 由直", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "447356", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柏倉 幾郎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "447357", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/45047", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-12-13"}, "publish_date": "2007-12-13", "publish_status": "0", "recid": "45047", "relation": {}, "relation_version_is_last": true, "title": ["Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation"], "weko_shared_id": -1}
Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation
https://repo.qst.go.jp/records/45047
https://repo.qst.go.jp/records/45047e8df8449-7ae9-41a6-baf8-c1531886e60b
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-13 | |||||
タイトル | ||||||
タイトル | Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahashi, Kenji
× Takahashi, Kenji× Monzen, Satoru× Eguchi-Kasai, Kiyomi× Abe, Yoshinao× Kashiwakura, Ikuo× 高橋 賢次× 門前 暁× 笠井 清美× 阿部 由直× 柏倉 幾郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Heavy ions have a unique efficacy for tumor control in radiotherapy. To clarify the effects of heavy-ion beams on hematopoietic stem/progenitor cells, the effects of carbon-ion beams on megakaryocytopoiesis and thrombopoiesis in CD34(+) cells derived from human placental and umbilical cord blood were investigated. The cells were exposed to carbon-ion beams (LET = 50 keV/microm) and then were treated with thrombopoietin (TPO) alone or TPO plus other cytokines. Megakaryocytic progenitor cells, such as megakaryocyte colony-forming units (CFU-Meg), were far more sensitive to carbon-ion beams than to X rays, and no restoration of carbon-ion beam-irradiated CFU-Meg by treatment with any cytokine combination was observed. However, total cell expansion in liquid culture was not different after either carbon-ion beam or X irradiation of CD34(+) cells. The activation of gamma-H2AX, a marker of DNA double strand-breaks (DSBs), was promoted by the cytokine treatment in X-irradiated CD34(+) cells but not in carbon-ion-irradiated cells. These results showed that carbon-ion beams inflicted severe damage on megakaryocytopoiesis and thrombopoiesis and that a better combination of cytokines and other agents may be needed to stimulate the recovery of hematopoietic cells and repair this damage. |
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書誌情報 |
Radiation Research 巻 168, 号 5, p. 545-551, 発行日 2007-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0033-7587 |