{"created":"2023-05-15T14:34:50.684113+00:00","id":45047,"links":{},"metadata":{"_buckets":{"deposit":"16cd8b70-1095-4de4-b674-55f523230bd9"},"_deposit":{"created_by":1,"id":"45047","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45047"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045047","sets":["1"]},"author_link":["447353","447356","447351","447352","447355","447349","447357","447348","447354","447350"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"551","bibliographicPageStart":"545","bibliographicVolumeNumber":"168","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Heavy ions have a unique efficacy for tumor control in radiotherapy. To clarify\nthe effects of heavy-ion beams on hematopoietic stem/progenitor cells, the\neffects of carbon-ion beams on megakaryocytopoiesis and thrombopoiesis in CD34(+)\ncells derived from human placental and umbilical cord blood were investigated.\nThe cells were exposed to carbon-ion beams (LET = 50 keV/microm) and then were\ntreated with thrombopoietin (TPO) alone or TPO plus other cytokines.\nMegakaryocytic progenitor cells, such as megakaryocyte colony-forming units\n(CFU-Meg), were far more sensitive to carbon-ion beams than to X rays, and no\nrestoration of carbon-ion beam-irradiated CFU-Meg by treatment with any cytokine \ncombination was observed. However, total cell expansion in liquid culture was not\ndifferent after either carbon-ion beam or X irradiation of CD34(+) cells. The\nactivation of gamma-H2AX, a marker of DNA double strand-breaks (DSBs), was\npromoted by the cytokine treatment in X-irradiated CD34(+) cells but not in\ncarbon-ion-irradiated cells. These results showed that carbon-ion beams inflicted\nsevere damage on megakaryocytopoiesis and thrombopoiesis and that a better\ncombination of cytokines and other agents may be needed to stimulate the recovery\nof hematopoietic cells and repair this damage.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"447348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Monzen, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"447349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"447350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Yoshinao"}],"nameIdentifiers":[{"nameIdentifier":"447351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashiwakura, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"447352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 賢次","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"門前 暁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部 由直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柏倉 幾郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447357","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-13"},"publish_date":"2007-12-13","publish_status":"0","recid":"45047","relation_version_is_last":true,"title":["Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:08:18.538236+00:00"}