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A loss of function screen identifies nine new radiation susceptibility genes
https://repo.qst.go.jp/records/45037
https://repo.qst.go.jp/records/45037a8394256-4915-4f77-9f57-e5a5d3e63b9f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-30 | |||||
| タイトル | ||||||
| タイトル | A loss of function screen identifies nine new radiation susceptibility genes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sudou, Hitomi
× Sudou, Hitomi× Tsuji, Atsushi× Sugyou, Aya× Imai, Takashi× Saga, Tsuneo× Harada, Yoshinobu× 須藤 仁美× 辻 厚至× 須尭 綾× 今井 高志× 佐賀 恒夫× 原田 良信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Genomic instability is considered a hallmark of carcinogenesis, and dysfunction of DNA repair and cell cycle regulation in response to DNA damage caused by ionizing radiation are thought to be important factors in the early stages of genomic instability. We performed cell-based functional screening using an RNA interference library targeting 200 genes in human cells. We identified three known and nine new radiation susceptibility genes, eight of which are linked directly or potentially with cell cycle progression. Cell cycle analysis on four of the genes not previously linked to cell cycle progression demonstrated that one, ZDHHC8, was associated with the G(2)/M checkpoint in response to DNA damage. Further study of the 12 radiation susceptibility genes identified in this screen may help to elucidate the molecular mechanisms of cell cycle progression, DNA repair, cell death, cell growth and genomic instability, and to develop new radiation sensitizing agents for radiotherapy. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 364, 号 3, p. 695-701, 発行日 2007-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
