@article{oai:repo.qst.go.jp:00045037,
 author = {Sudou, Hitomi and Tsuji, Atsushi and Sugyou, Aya and Imai, Takashi and Saga, Tsuneo and Harada, Yoshinobu and 須藤 仁美 and 辻 厚至 and 須尭 綾 and 今井 高志 and 佐賀 恒夫 and 原田 良信},
 issue = {3},
 journal = {Biochemical and Biophysical Research Communications},
 month = {Dec},
 note = {Genomic instability is considered a hallmark of carcinogenesis, and dysfunction of DNA repair and cell cycle regulation in response to DNA damage caused by ionizing radiation are thought to be important factors in the early stages of genomic instability. We performed cell-based functional screening using an RNA interference library targeting 200 genes in human cells. We identified three known and nine new radiation susceptibility genes, eight of which are linked directly or potentially with cell cycle progression. Cell cycle analysis on four of the genes not previously linked to cell cycle progression demonstrated that one, ZDHHC8, was associated with the G(2)/M checkpoint in response to DNA damage. Further study of the 12 radiation susceptibility genes identified in this screen may help to elucidate the molecular mechanisms of cell cycle progression, DNA repair, cell death, cell growth and genomic instability, and to develop new radiation sensitizing agents for radiotherapy.},
 pages = {695--701},
 title = {A loss of function screen identifies nine new radiation susceptibility genes},
 volume = {364},
 year = {2007}
}