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Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI.
https://repo.qst.go.jp/records/44890
https://repo.qst.go.jp/records/44890c6739089-3416-432b-aef4-41af167f3a02
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-19 | |||||
| タイトル | ||||||
| タイトル | Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kim, Tae
× Kim, Tae× S, Hendrich Kristy× Masamoto, Kazuto× Kim, Seong-Gi× 正本 和人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Quantifying both arterial cerebral blood volume (CBVa) changes and total cerebral blood volume (CBVt) changes during neural activation can provide critical information about vascular control mechanisms, and help to identify the origins of neurovascular responses in conventional blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI). Cerebral blood flow (CBF), CBVa, and CBVt quantified by MRI at 9.4 T in isoflurane-anesthetized rats during 15-s duration forepaw stimulation. Cerebral blood flow and CBVa were simultaneously determined by modulation of tissue and vessel signals using arterial spin labeling, while CBVt was measured with a susceptibility-based contrast agent. Baseline versus stimulation values in a region centered over the somatosensory cortex were: CBF = 150618 versus 182620 mL/100 g/min, CBVa = 0.8360.21 versus 1.1760.30mL/100 g, CBVt = 3.1060.55 versus 3.4160.61 mL/100 g, and CBVa/CBVt60.2760.05 versus 0.3460.06 (n=7, mean6s.d.). Absolute changes in CBVa and CBVt because of activation are statistically equivalent and independent of the spatial extent of regional analysis. Under our conditions, increased CBVt during neural activation is mainly because of arterial rather than venous blood volume changes, and therefore a critical implication is that venous blood volume changes may be negligible in BOLD fMRI. |
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| 書誌情報 |
Journal of Cerebral Blood Flow and Metabolism 巻 27, 号 6, p. 1235-1247, 発行日 2006-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/sj.jcbfm.9600429 | |||||
