@article{oai:repo.qst.go.jp:00044890,
 author = {Kim, Tae and S, Hendrich Kristy and Masamoto, Kazuto and Kim, Seong-Gi and 正本 和人},
 issue = {6},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {Dec},
 note = {Quantifying both arterial cerebral blood volume (CBVa) changes and total cerebral blood volume (CBVt) changes during neural activation can provide critical information about vascular control mechanisms, and help to identify the origins of neurovascular responses in conventional blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI). Cerebral blood flow (CBF), CBVa, and CBVt quantified by MRI at 9.4 T in isoflurane-anesthetized rats during 15-s duration forepaw stimulation. Cerebral blood flow and CBVa were simultaneously determined by modulation of tissue and vessel signals using arterial spin labeling, while CBVt was measured with a susceptibility-based contrast agent. Baseline versus stimulation values in a region centered over the somatosensory cortex were: CBF = 150618 versus 182620 mL/100 g/min, CBVa = 0.8360.21 versus 1.1760.30mL/100 g, CBVt = 3.1060.55 versus 3.4160.61 mL/100 g, and CBVa/CBVt60.2760.05 versus 0.3460.06 (n=7, mean6s.d.). Absolute changes in CBVa and CBVt because of activation are statistically equivalent and independent of the spatial extent of regional analysis. Under our conditions, increased CBVt during neural activation is mainly because of arterial rather than venous blood volume changes, and therefore a critical implication is that venous blood volume changes
may be negligible in BOLD fMRI.},
 pages = {1235--1247},
 title = {Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: implication for BOLD fMRI.},
 volume = {27},
 year = {2006}
}