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Amelioration of Type II Diabetes in db/db Mice by Continuous Low Dose-Rate gamma-Irradiation
https://repo.qst.go.jp/records/44854
https://repo.qst.go.jp/records/4485449d9b7ad-5d1e-4c48-bff4-5332c0d3c7b8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-28 | |||||
| タイトル | ||||||
| タイトル | Amelioration of Type II Diabetes in db/db Mice by Continuous Low Dose-Rate gamma-Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuruga, Mie
× Tsuruga, Mie× Taki, Keiko× et.al× 瀧 景子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Low dose-rate irradiation modulates various biological responses including carcinogenesis, immunological responses and diabetes. Here we found that continuous irradiation with low dose-rate gamma-rays ameliorated type II diabetes in db/db mice, diabeticmice lacking leptin receptors. Whole body exposure of db/db mice to low dose-rate gamma-irradiation improved glucose clearance without affecting response to insulin. Histological study suggested that degeneration of pancreatic islets was significantlysuppressed by the irradiation. Insulin secretion in response to glucose loading wassignificantly increased in the irradiated mice. These results suggest that low dose-rate gamma-irradiation ameliorates type II diabetes by maintaining insulin secretion, whichgradually decreases in the progress of diabetes due to degeneration of pancreatic islets. We also inferred that protection from oxidative damage is involved in the anti-diabetic effect of low dose-rate gamma-ray because expression and activity of pancreatic superoxide dismutase were significantly elevated by the low dose-rate gamma-irradiation. |
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| 書誌情報 |
Radiation Research 巻 167, 号 5, p. 592-599, 発行日 2007-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
