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Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
https://repo.qst.go.jp/records/44807
https://repo.qst.go.jp/records/448079f14385f-b6fc-4522-b388-88ff2b6c4daf
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-03-15 | |||||
| タイトル | ||||||
| タイトル | Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Noguchi, Miho
× Noguchi, Miho× Yu, Dong× Hirayama, Ryoichi× Ninomiya, Yasuharu× Sekine, Emiko× Kubota, Nobuo× Ando, Koichi× Okayasu, Ryuichi× 野口 実穂× 于 冬× 平山 亮一× 二宮 康晴× 関根 絵美子× 窪田 宜夫× 安藤 興一× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to investigate the mechanism of radio-sensitization by an Hsp90 inhibitor 17-Allylamino-17-demethoxygeldanamucin (17-AAG), we studied repair of DNA double strand breaks (DSBs) in irradiated human cells pre-treated with 17-AAG DSBs are thought to be the critical target for radiation-induced cell death. Two human tumor cell lines DU145 and SQ-5 which showed clear radio-sensitization by 17-AAG revealed a significant inhibition of DSB repair, while normal human cells which did not show radio-sensitization by the drug indicated no change in the DSB repair kinetics with 17AAG. We further demonstrated that BRCA2 was a novel client protein for Hsp90, and 17-AAG caused the degradation of BRCA2 and in turn altered the behavior of Rad51, a critical protein for homologous recombination (HR) pathway of DSB repair. Our data demonstrate for the first time that 17-AAG inhibits the HR repair process and could provide a new therapeutic strategy to selectively result in higher tumor cell killing. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 351, 号 3, p. 658-663, 発行日 2006-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
