{"created":"2023-05-15T14:34:40.240991+00:00","id":44807,"links":{},"metadata":{"_buckets":{"deposit":"14f68a81-60c4-4840-822a-5b1bf348e85a"},"_deposit":{"created_by":1,"id":"44807","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44807"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044807","sets":["1"]},"author_link":["444927","444915","444926","444929","444924","444918","444916","444919","444930","444928","444917","444920","444923","444922","444921","444925"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"663","bibliographicPageStart":"658","bibliographicVolumeNumber":"351","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to investigate the mechanism of radio-sensitization by an Hsp90 inhibitor 17-Allylamino-17-demethoxygeldanamucin (17-AAG), we studied repair of DNA double strand breaks (DSBs) in irradiated human cells pre-treated with 17-AAG DSBs are thought to be the critical target for radiation-induced cell death. Two human tumor cell lines DU145 and SQ-5 which showed clear radio-sensitization by 17-AAG revealed a significant inhibition of DSB repair, while normal human cells which did not show radio-sensitization by the drug indicated no change in the DSB repair kinetics with 17AAG. We further demonstrated that BRCA2 was a novel client protein for Hsp90, and 17-AAG caused the degradation of BRCA2 and in turn altered the behavior of Rad51, a critical protein for homologous recombination (HR) pathway of DSB repair. Our data demonstrate for the first time that 17-AAG inhibits the HR repair process and could provide a new therapeutic strategy to selectively result in higher tumor cell killing.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noguchi, Miho"}],"nameIdentifiers":[{"nameIdentifier":"444915","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yu, Dong"}],"nameIdentifiers":[{"nameIdentifier":"444916","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"444917","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"444918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekine, Emiko"}],"nameIdentifiers":[{"nameIdentifier":"444919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"444920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"444921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"444922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野口 実穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"于 冬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根 絵美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"窪田 宜夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444930","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-03-15"},"publish_date":"2007-03-15","publish_status":"0","recid":"44807","relation_version_is_last":true,"title":["Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:11:07.395534+00:00"}