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Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone
https://repo.qst.go.jp/records/44769
https://repo.qst.go.jp/records/4476951f14750-d154-4968-bb49-d67bb7dfb159
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-01-15 | |||||
| タイトル | ||||||
| タイトル | Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohno, Tatsuya
× Ohno, Tatsuya× Kato, Shingo× Wakatuki, Masaru× Noda, Shinei× Murakami, Chiemi× Nakamura, Misako× Tsujii, Hirohiko× 大野 達也× 加藤 眞吾× 若月 優× 野田 真永× 村上 ちゑみ× 中村 美佐子× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract Objective: To investigate the temporal patterns of anorexia, diarrhea, weight loss, and leukopenia in chemoradiation therapy (CRT) for cervical cancer compared with radiation therapy (RT) alone. Methods: Thirty-eight patients receiving RT alone and 30 patients receiving CRT were studied. Patients were treated with a combination of external beam irradiation and high-dose rate intracavitary irradiation. Cisplatin was given once a week for five weeks concurrently with the external beam irradiation. CRT was divided into low-dose CRT group (cisplatin, 20-30 mg/m2, n=16) and high-dose CRT group (cisplatin, 35-40 mg/m2, n=14). Toxicities were evaluated before, every week up to 7 weeks during the cycle, and 12 weeks after initial irradiation, according to the National Cancer Institute Common Toxicity Criteria. Results: In the high-dose CRT group, anorexia during the first 5 weeks, leukopenia after 5 weeks, and weight loss at 6 weeks were significantly higher than those in the RT alone group. In the low-dose CRT group, anorexia at 2 weeks, leukopenia after 5 weeks, and weight loss between 3 and 4 weeks were significantly higher than those in the RT alone group but the levels of toxicities were lower than those in the high-dose CRT group. There was no significant difference in the pattern of diarrhea between the RT alone and high-dose CRT groups, and it was significantly lower in the low-dose CRT group compared with RT alone. Conclusion: These data can help us to understand when patients are likely to develop maximal toxicities and to manage them with optimal timing. |
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| 書誌情報 |
Gynecologic Oncology 巻 103, 号 1, p. 94-99, 発行日 2006-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0090-8258 | |||||
