@article{oai:repo.qst.go.jp:00044769,
 author = {Ohno, Tatsuya and Kato, Shingo and Wakatuki, Masaru and Noda, Shinei and Murakami, Chiemi and Nakamura, Misako and Tsujii, Hirohiko and 大野 達也 and 加藤 眞吾 and 若月 優 and 野田 真永 and 村上 ちゑみ and 中村 美佐子 and 辻井 博彦},
 issue = {1},
 journal = {Gynecologic Oncology},
 month = {Oct},
 note = {Abstract
Objective: To investigate the temporal patterns of anorexia, diarrhea,
weight loss, and leukopenia in chemoradiation therapy (CRT) for cervical
cancer compared with radiation therapy (RT) alone.
Methods: Thirty-eight patients receiving RT alone and 30 patients
receiving CRT were studied.  Patients were treated with a combination of
external beam irradiation and high-dose rate intracavitary irradiation.
 Cisplatin was given once a week for five weeks concurrently with the
external beam irradiation.  CRT was divided into low-dose CRT group
(cisplatin, 20-30 mg/m2, n=16) and high-dose CRT group (cisplatin, 35-40
mg/m2, n=14).  Toxicities were evaluated before, every week up to 7
weeks during the cycle, and 12 weeks after initial irradiation,
according to the National Cancer Institute Common Toxicity Criteria.
Results: In the high-dose CRT group, anorexia during the first 5 weeks,
leukopenia after 5 weeks, and weight loss at 6 weeks were significantly
higher than those in the RT alone group.  In the low-dose CRT group,
anorexia at 2 weeks, leukopenia after 5 weeks, and weight loss between 3
and 4 weeks were significantly higher than those in the RT alone group
but the levels of toxicities were lower than those in the high-dose CRT
group.  There was no significant difference in the pattern of diarrhea
between the RT alone and high-dose CRT groups, and it was significantly
lower in the low-dose CRT group compared with RT alone.
Conclusion: These data can help us to understand when patients are
likely to develop maximal toxicities and to manage them with optimal timing.},
 pages = {94--99},
 title = {Incidence and temporal pattern of anorexia, diarrhea, weight loss,and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin:comparison with radiation therapy alone},
 volume = {103},
 year = {2006}
}