WEKO3
アイテム
Threshold dose problems in radiation carcinogenesis: A review of non-tumor doses
https://repo.qst.go.jp/records/44680
https://repo.qst.go.jp/records/446809ba3f72a-f019-4940-9623-4cc10bc17ed3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-10-20 | |||||
| タイトル | ||||||
| タイトル | Threshold dose problems in radiation carcinogenesis: A review of non-tumor doses | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tanooka, Hiroshi
× Tanooka, Hiroshi× 田ノ岡 宏 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Non-tumour-inducing doses exist in dose-response data on experimental animals and humans, although a linear non-threshold model has been adopted for estimating cancer risk of ionising radiation at a low dose region for radiation protection purposes. Here, data on non- tumour dose, Dnt, the maximum dose at which a statistically significant increase of tumours is not observed, were reviewed in the literature. Dnt values range from 0.1 to 3 Gy for a variety of tumours induced by acute whole-body irradiation at low LET. This becomes one order higher by fractionation of radiation dose and further by extending irradiation chronically. Non-tumour doses for irradiation of a part of the body are one order higher than those for whole-body irradiation, indicating a higher tolerance level in the partial-body irradiation. Tumour data with high LET radiation also show non-tumour dose and its decrease at a very low dose rate. The variation of Dnt is explained by the host tolerance, including inducible and non-inducible DNA repair, apoptotic elimination of unrepaired cells, and immunological suppression of tumour development. | |||||
| 書誌情報 |
International Journal of Low Radiation 巻 1, 号 3, p. 329-333, 発行日 2004 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1477-6545 | |||||
