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Evaluation of Phenylmethanesulfonyl fluoride (PMSF) as a Tracer Candidate Mapping Acetylcholinesterase In Vivo
https://repo.qst.go.jp/records/44445
https://repo.qst.go.jp/records/444452644aad1-9774-488d-a338-600a3d6c727a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-07 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Phenylmethanesulfonyl fluoride (PMSF) as a Tracer Candidate Mapping Acetylcholinesterase In Vivo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Irie, Toshiaki
× Irie, Toshiaki× Fukushi, Kiyoshi× Iyo, Masaomi× 入江 俊章× 福士 清 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The availability of phenylmethanesulfonyl fluoride (PMSF), an irreversible cholinesterase inhibitor, for a tracer mapping acetylcholinesterase (AchE) in vivo in brain and other organs was evaluated using [35S]PMSF in mice and rats.[35X]PMSF was well taken up into the brain, heart and muscle, and the radioactivities were trapped in these organs. Pretreatment with non-labeled PMSF decreased 33-40% of the trapped radioactivities in the brain and other organs in mice. However, regional distribution of [35S]PMSF in rat brain didi not correlate well withthat of AchE activity, suggesting that tha selectivity of PMSF toward AchE may be insufficient for use as an in vivo tracer mapping AchE. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 20, 号 8, p. 991-992, 発行日 1993 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
