{"created":"2023-05-15T14:34:24.137698+00:00","id":44445,"links":{},"metadata":{"_buckets":{"deposit":"4963ca08-06bf-48a3-8625-c8b04fb0e0b4"},"_deposit":{"created_by":1,"id":"44445","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44445"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044445","sets":["1"]},"author_link":["441677","441681","441679","441678","441680"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"992","bibliographicPageStart":"991","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The availability of phenylmethanesulfonyl fluoride (PMSF), an irreversible cholinesterase inhibitor, for a tracer mapping acetylcholinesterase (AchE) in vivo in brain and other organs was evaluated using [35S]PMSF in mice and rats.[35X]PMSF was well taken up into the brain, heart and muscle, and the radioactivities were trapped in these organs. Pretreatment with non-labeled PMSF decreased 33-40% of the trapped radioactivities in the brain and other organs in mice. However, regional distribution of [35S]PMSF in rat brain didi not correlate well withthat of AchE activity, suggesting that tha selectivity of PMSF toward AchE may be insufficient for use as an in vivo tracer mapping AchE.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"441677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"441678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iyo, Masaomi"}],"nameIdentifiers":[{"nameIdentifier":"441679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441681","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of Phenylmethanesulfonyl fluoride (PMSF) as a Tracer Candidate Mapping Acetylcholinesterase In Vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Phenylmethanesulfonyl fluoride (PMSF) as a Tracer Candidate Mapping Acetylcholinesterase In Vivo"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-07"},"publish_date":"2006-07-07","publish_status":"0","recid":"44445","relation_version_is_last":true,"title":["Evaluation of Phenylmethanesulfonyl fluoride (PMSF) as a Tracer Candidate Mapping Acetylcholinesterase In Vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:15:22.787920+00:00"}