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Brain Acetylcholinesterase Activity in Alzheimer Disease Measure by Positron Emission Tomography
https://repo.qst.go.jp/records/44415
https://repo.qst.go.jp/records/4441564bd35cc-8a99-4c83-98c7-bce0c6d9514c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-06 | |||||
| タイトル | ||||||
| タイトル | Brain Acetylcholinesterase Activity in Alzheimer Disease Measure by Positron Emission Tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× Namba, Hiroki× Fukushi, Kiyoshi× Nagatsuka, Shinnichiro× Tanaka, Noriko× Aotsuka, Akiyo× Tanada, Shuji× Irie, Toshiaki× 篠遠 仁× 難波 宏樹× 福士 清× 長塚 伸一郎× 田中 典子× 青墳 章代× 棚田 修二× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Brain acetylcholinesterase activity was measured in 14 patients with Alzheimer disease and 14 age-matched control subjects by positron emission tomography with a radioactive acetylcholine. Kinetic analysis was performed to calculate k3, an index of acetylcholinesterase activity. The k3 values were significantly reduced in the necortex, hippocampus, and amygdata of all patients with Alzheimer disease, suggesting a loss of cholinergic innervation from the basal forebrain. Most profound reductions of k3 values were observed in the temporal (-30%) and parietal cortices (-31%), although reductions of k3 values were relatively uniform in the cerebral neocortex. This technique may be a powerful tool for early diagnosis of Alzheimer disease and also for therapeutic monitoring of acetylcholinesterase inhibitors in Alzeimer disease. | |||||
| 書誌情報 |
Alzheimer Disease and Associated Disorders 巻 14, p. S114-S118, 発行日 2000 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0893-0341 | |||||
