@article{oai:repo.qst.go.jp:00044415,
 author = {Shinoto, Hitoshi and Namba, Hiroki and Fukushi, Kiyoshi and Nagatsuka, Shinnichiro and Tanaka, Noriko and Aotsuka, Akiyo and Tanada, Shuji and Irie, Toshiaki and 篠遠 仁 and 難波 宏樹 and 福士 清 and 長塚 伸一郎 and 田中 典子 and 青墳 章代 and 棚田 修二 and 入江 俊章},
 journal = {Alzheimer Disease and Associated Disorders},
 month = {},
 note = {Brain acetylcholinesterase activity was measured in 14 patients with Alzheimer disease and 14 age-matched control subjects by positron emission tomography with a radioactive acetylcholine. Kinetic analysis was performed to calculate k3, an index of acetylcholinesterase activity. The k3 values were significantly reduced in the necortex, hippocampus, and amygdata of all patients with Alzheimer disease, suggesting a loss of cholinergic innervation from the basal forebrain.  Most profound reductions of k3 values were observed in the temporal (-30%) and parietal cortices (-31%), although reductions of k3 values were relatively uniform in the cerebral neocortex. This technique may be a powerful tool for early diagnosis of Alzheimer disease and also for therapeutic monitoring of acetylcholinesterase inhibitors in Alzeimer disease.},
 pages = {S114--S118},
 title = {Brain  Acetylcholinesterase Activity in Alzheimer Disease Measure by Positron Emission Tomography},
 volume = {14},
 year = {2000}
}