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Kinetic Analysis of [11C] MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling
https://repo.qst.go.jp/records/44404
https://repo.qst.go.jp/records/444044971e475-e97c-4d49-baa4-60ccd4beb16b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-04 | |||||
| タイトル | ||||||
| タイトル | Kinetic Analysis of [11C] MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nagatsuka, Shin-ichiro
× Nagatsuka, Shin-ichiro× Fukushi, Kiyoshi× Shinotoh, Hitoshi× Namba, Hiroki× Iyo, Masaomi× Tanaka, Noriko× Aotsuka, Akiyo× Ota, Tsuneyoshi× Tanada, Shuji× Irie, Toshiaki× 長塚 伸一郎× 福士 清× 篠遠 仁× 難波 宏樹× 田中 典子× 青墳 章代× 黄田 常嘉× 棚田 修二× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | N-[11C]methylpiperidin-4-yl acetate([11C]MP4A) is an acetylcholine analog. It has been used successfully for the quantitative measurement of acetylcholinesterase(AChE) activity in the human brain with positron emission tomography(PET). [11C]MP4A is specifically hydrolyzed by AChE in the brain to a hydrophilic metabolite,which is irreversibly trapped locally in the brain. The authors propose a new method of kinetic analysis of brain AChE activity by PET without arterial blood sampling,that is reference tissue-based ;omear ;east squares(RLS) analysis. In this method, cerebellum or striatum is used as a reference tissue. These regions, because of their high AChE activity, act as a biologic integrator of plasma input function during PET scanning, when regional metabolic rates of [11C] MP4A through AChE(k3,an AChE index) are calculated by using Blomqvist s linear least squares analysis. Computer simulation studies showed that RLS analysis yielded k3 with almost the same accuracy as the standard nonlinear least squares(NLS) analysis in brain regions with low (such as neocortex and hippocampus) and monderately high (thalamus) k3 vallues. The authors then applied these methods to [11C]MP4A PET data in 12 healthy subjects and 26patients with Alzheimer disease(AD) using the cerebellum as the reference region. There was a highly significant linear correlation in regional k3 estimates between RLS and NLS analysis (456 cerebral regions,[RLS k3]=0.98x[NLS ks],gamma=0.92,P<0.001). Significant reductions were observed in k3 estimates of frontal,temporal,parietal,occipital,and sensorimotor cerebral neocortics (P<0.001,single-tailed t-test),and hippocampus(P=0.012) in patients with AD as compared with controls when using RLS analysis. Mean reductions (19.6 )in these 6 regions by RLS were almost the same as those by NLS analysis (20.5 ). The sensitivity of RLS analysis for detecting cortical regions with abnormally low k3 in the 26 patients with AD(138 of 312 regions,44 ) was somewhat less than NLS analysis (52 ),But was greater than shape analysis (33 ),another method of [11C]MP4A kinetic analysis without blood sampling. The authors conclude that RLS analysis is practical and useful for routine analysis of clinical {11C]MP4A studies. | |||||
| 書誌情報 |
Journal of Cerebral Blood Flow and Metabolism 巻 21, p. 1354-1366, 発行日 2001 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
