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Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study
https://repo.qst.go.jp/records/44324
https://repo.qst.go.jp/records/443241e5d0646-ce27-4c81-8e73-773d7952dfce
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-23 | |||||
| タイトル | ||||||
| タイトル | Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Noguchi, Junko
× Noguchi, Junko× Suzuki, Kazutoshi× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have designed and constructed an automated device for the production of ultra-high specific activity 11C-labeled compounds via [11C]CH3I synthesized by the single pass I2 method. The optimum condition for the production of[11C]CH3I was determined to be 630degree C for oven-1 (reaction column), 50degree C for oven-2 (iodine column) and 50 ml/min for the He gas flow rate, and gave the maximum conversion ratio of [11C]CH3I,44%. [11C]Ro15-4513, known as an inverse agonist of the benzodiazepine receptor, was produced under optimized conditions. An i.v.injectable[11C]Ro15-4513 solution of 1500+/-490 MBq (n=6) with specific activity 4700+/-2500 GBq/mumol and a radiochemical purity of 98.2+/-2% was obtained automatically within 25 minutes (from EOB) by irradiating nitrogen gas containing 5% H2 with 18 MeV protons (14,2 MeV on target) at 20 muA for 20 minutes. The highest specific activity of 9700 GBq/mumol (at EOS) could be achieved,although the radiochemical purity was 92.4%. By the use of the ultra-high specific activity [11C]Ro15-4513,the super high affinity binding sites in the rat brain hippocampus could be clearly visualized even at the extremely low concentration of 0.66 pM Ro15-4513 by in vitro autoradiography. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 30, p. 335-343, 発行日 2003-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
