{"created":"2023-05-15T14:34:16.506964+00:00","id":44324,"links":{},"metadata":{"_buckets":{"deposit":"4ab2a95f-6e2d-4462-8d47-b79947119783"},"_deposit":{"created_by":1,"id":"44324","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44324"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044324","sets":["1"]},"author_link":["440285","440286","440284"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"343","bibliographicPageStart":"335","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have designed and constructed an automated device for the production of ultra-high specific activity 11C-labeled compounds via [11C]CH3I synthesized by the single pass I2 method. The optimum condition for the production of[11C]CH3I was determined to be 630degree C for oven-1 (reaction column), 50degree C for oven-2 (iodine column) and 50 ml/min for the He gas flow rate, and gave the maximum conversion ratio of [11C]CH3I,44%. [11C]Ro15-4513, known as an inverse agonist of the benzodiazepine receptor, was produced under optimized conditions. An i.v.injectable[11C]Ro15-4513 solution of 1500+/-490 MBq (n=6) with specific activity 4700+/-2500 GBq/mumol and a radiochemical purity of 98.2+/-2% was obtained automatically within 25 minutes (from EOB) by irradiating nitrogen gas containing 5% H2 with 18 MeV protons (14,2 MeV on target) at 20 muA for 20 minutes. The highest specific activity of 9700 GBq/mumol (at EOS) could be achieved,although the radiochemical purity was 92.4%. By the use of the ultra-high specific activity [11C]Ro15-4513,the super high affinity binding sites in the rat brain hippocampus could be clearly visualized even at the extremely low concentration of 0.66 pM Ro15-4513 by in vitro autoradiography.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noguchi, Junko"}],"nameIdentifiers":[{"nameIdentifier":"440284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440286","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-23"},"publish_date":"2006-06-23","publish_status":"0","recid":"44324","relation_version_is_last":true,"title":["Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:16:47.894565+00:00"}