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Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column
https://repo.qst.go.jp/records/44304
https://repo.qst.go.jp/records/44304d906b60d-4bbc-4727-b0fb-284d562c0771
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-21 | |||||
| タイトル | ||||||
| タイトル | Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sasaki, Motoji
× Sasaki, Motoji× Ikemoto, Masahiro× Mutou, Masatoshi× Haradahira, Terushi× Tanaka, Akira× Watanabe, Yoshito× Suzuki, Kazutoshi× 佐々木 基仁× 池本 昌弘× 原田平 輝志× 渡辺 嘉人× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have developed a system for the automatic synthesis of L-[beta-11C]amino acids for i.v.injection by means of enzyme-mediated reactions from 11CO2 via 11CH3I and D,L-[beta-11C]alanine as labeled intermediates. This system, which incorporates an ultrafilter cartridge sterilized by electron beam irradiation and a column packed with immobilized enzymes, was effective for eliminating enzymes and endotoxins that may contaminate the product. Using this system, 1.3+/-0.5GBq of 5-hydroxy-L-[beta-11C]tryptophan with a radiochemical purity of 97.1+/-0.6% and a specific activity of 39.6+/-8 GBq/mumol a pH value of 4 could be obtained in about 32 min(n=3,at EOS). No endotoxin, enzyme, or bacteria was detected in the product. L-[beta-11C} dihydroxyphenylalanine (L-[beta-11C]DOPA) was also synthesized using this system. | |||||
| 書誌情報 |
Applied Radiation and Isotopes 巻 52, p. 199-204, 発行日 2000 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
