WEKO3
-
RootNode
アイテム
Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column
https://repo.qst.go.jp/records/44304
https://repo.qst.go.jp/records/44304d906b60d-4bbc-4727-b0fb-284d562c0771
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2006-06-21 | |||||
タイトル | ||||||
タイトル | Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Sasaki, Motoji
× Sasaki, Motoji× Ikemoto, Masahiro× Mutou, Masatoshi× Haradahira, Terushi× Tanaka, Akira× Watanabe, Yoshito× Suzuki, Kazutoshi× 佐々木 基仁× 池本 昌弘× 原田平 輝志× 渡辺 嘉人× 鈴木 和年 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have developed a system for the automatic synthesis of L-[beta-11C]amino acids for i.v.injection by means of enzyme-mediated reactions from 11CO2 via 11CH3I and D,L-[beta-11C]alanine as labeled intermediates. This system, which incorporates an ultrafilter cartridge sterilized by electron beam irradiation and a column packed with immobilized enzymes, was effective for eliminating enzymes and endotoxins that may contaminate the product. Using this system, 1.3+/-0.5GBq of 5-hydroxy-L-[beta-11C]tryptophan with a radiochemical purity of 97.1+/-0.6% and a specific activity of 39.6+/-8 GBq/mumol a pH value of 4 could be obtained in about 32 min(n=3,at EOS). No endotoxin, enzyme, or bacteria was detected in the product. L-[beta-11C} dihydroxyphenylalanine (L-[beta-11C]DOPA) was also synthesized using this system. | |||||
書誌情報 |
Applied Radiation and Isotopes 巻 52, p. 199-204, 発行日 2000 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-8043 |
Share
Cite as
Sasaki, Motoji, Ikemoto, Masahiro, Mutou, Masatoshi, Haradahira, Terushi, Tanaka, Akira, Watanabe, Yoshito, Suzuki, Kazutoshi, 佐々木 基仁, 池本 昌弘, 原田平 輝志, 渡辺 嘉人, 鈴木 和年, n.d., Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column: 199–204 p.
Loading...