{"created":"2023-05-15T14:34:15.182886+00:00","id":44304,"links":{},"metadata":{"_buckets":{"deposit":"8d3caf51-2258-4cfd-a1c8-0b1983f756a6"},"_deposit":{"created_by":1,"id":"44304","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44304"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044304","sets":["1"]},"author_link":["440063","440061","440070","440069","440067","440062","440066","440068","440071","440064","440065","440072"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"204","bibliographicPageStart":"199","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Applied Radiation and Isotopes"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed a system for the automatic synthesis of L-[beta-11C]amino acids for i.v.injection by means of enzyme-mediated reactions from 11CO2 via 11CH3I and D,L-[beta-11C]alanine as labeled intermediates. This system, which incorporates an ultrafilter cartridge sterilized by electron beam irradiation and a column packed with immobilized enzymes, was effective for eliminating enzymes and endotoxins that may contaminate the product.  Using this system, 1.3+/-0.5GBq of 5-hydroxy-L-[beta-11C]tryptophan with a radiochemical purity of 97.1+/-0.6% and a specific activity of 39.6+/-8 GBq/mumol a pH value of 4 could be obtained in about 32 min(n=3,at EOS).  No endotoxin, enzyme, or bacteria was detected in the product.  L-[beta-11C} dihydroxyphenylalanine (L-[beta-11C]DOPA) was also synthesized using this system.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8043","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Motoji"}],"nameIdentifiers":[{"nameIdentifier":"440061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikemoto, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"440062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mutou, Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"440063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"440064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Akira"}],"nameIdentifiers":[{"nameIdentifier":"440065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yoshito"}],"nameIdentifiers":[{"nameIdentifier":"440066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 基仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池本 昌弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 嘉人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440072","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-21"},"publish_date":"2006-06-21","publish_status":"0","recid":"44304","relation_version_is_last":true,"title":["Automatic synthesis of L-[beta-11C]amino acids using an immobilized enzyme column"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:17:02.128656+00:00"}