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Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression
https://repo.qst.go.jp/records/44244
https://repo.qst.go.jp/records/4424456253762-fc64-4d55-bafe-2665ab6d7a96
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ban, Sadayuki
× Ban, Sadayuki× Ishikawa, Ken-ichi× Kawai, Seiko× Saegusa, Kumiko× Ishikawa, Atsuko× Shimada, Yutaka× Inazawa, Jouji× Imai, Takashi× 伴 貞幸× 石川 顕一× 川井 聖子× 三枝 公美子× 石川 敦子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Morphologically heterogeneous colonies were formed from a cultured cell line (KYSE70) established from one human esophageal carcinoma tissue. Two subclones were separated from a single clone (clone13) of KYSE70 cells. One subclone (clone13-3G) formed mainly mounding colonies and the other (clone 13-6G) formed flat, diffusive colonies. X-irradiation stimulated the cells to dedifferentiate from the mounding state to the flat, diffusive state. Clone 13-6G cells were more radiosensitive than the other 3 cell lines. Clustering analysis for gene expression level by oligonucleotide microarray demonstrated that in the radiosensitive clone13-6G cells, expression of genes involved in cell adhesion was upregulated, but genes involved in the response to DNA damage stimulus were downregulated. The data demonstrated that a single cancer cell had the potential to produce progeny heterogeneous in terms of morphology, radiation sensitivity and gene expression, and irradiation enhanced the dedifferentiation of cancer cells. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 46, 号 1, p. 43-50, 発行日 2005-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
