{"created":"2023-05-15T14:34:11.208571+00:00","id":44244,"links":{},"metadata":{"_buckets":{"deposit":"4fe25140-4b18-433c-afca-dab1fdd2c5fb"},"_deposit":{"created_by":1,"id":"44244","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44244"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044244","sets":["1"]},"author_link":["439580","439578","439575","439579","439571","439582","439581","439573","439577","439576","439572","439574","439584","439583"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"50","bibliographicPageStart":"43","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Morphologically heterogeneous colonies were formed from a cultured cell line (KYSE70) established from one human esophageal carcinoma tissue. Two subclones were separated from a single clone (clone13) of KYSE70 cells. One subclone (clone13-3G) formed mainly mounding colonies and the other (clone 13-6G) formed flat, diffusive colonies. X-irradiation stimulated the cells to dedifferentiate from the mounding state to the flat, diffusive state. Clone 13-6G cells were more radiosensitive than the other 3 cell lines. Clustering analysis for gene expression level by oligonucleotide microarray demonstrated that in the radiosensitive clone13-6G cells, expression of genes involved in cell adhesion was upregulated, but genes involved in the response to DNA damage stimulus were downregulated. The data demonstrated that a single cancer cell had the potential to produce progeny heterogeneous in terms of morphology, radiation sensitivity and gene expression, and irradiation enhanced the dedifferentiation of cancer cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ban, Sadayuki"}],"nameIdentifiers":[{"nameIdentifier":"439571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Ken-ichi"}],"nameIdentifiers":[{"nameIdentifier":"439572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Seiko"}],"nameIdentifiers":[{"nameIdentifier":"439573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saegusa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"439574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"439575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"439576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inazawa, Jouji"}],"nameIdentifiers":[{"nameIdentifier":"439577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"439578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伴 貞幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 顕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川井 聖子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三枝 公美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439584","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-13"},"publish_date":"2006-06-13","publish_status":"0","recid":"44244","relation_version_is_last":true,"title":["Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:17:45.128920+00:00"}