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Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis
https://repo.qst.go.jp/records/44130
https://repo.qst.go.jp/records/441305cdb4b89-71e2-448f-8422-afcf86b92c8b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-31 | |||||
| タイトル | ||||||
| タイトル | Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Nishimura, Yukiko× Kakinuma, Shizuko× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 西村 由希子× 柿沼 志津子× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The rat model of radiation-induced carcinogenesis is widely used to estimate breast cancer risk, but it is unknown whether mammary terminal end buds (TEBs), the hypothesized target of chemical carcinogens, are also targets of radiation-induced carcinogenesis. Materials and Methods: Female Sprague-Dawley rats were irradiated with X-rays (2 Gy). The morphology, bromodeoxyuridine (BrdU)-labeling index and pyknotic index of mammary ductal termini were investigated from 6 hours to 8 weeks post-irradiation. Results: Irradiated rats showed a significantly smaller decrease in TEB numbers than controls 4 weeks after irradiation. The BrdU-labeling and pyknotic indexes initially decreased and increased, respectively, recovered to control levels by 3 days post-irradiation, and remained significantly higher until 8 weeks and at 4 weeks post-irradiation, respectively. One case of ductal hyperplasia was observed at 8 weeks. Conclusions: Irradiation resulted in a persistent proliferation of TEBs, which may be associated with neoplastic transformation via a temporal differentiation arrest. |
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| 書誌情報 |
In Vivo 巻 20, 号 3, p. 353-358, 発行日 2006-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0258-851X | |||||
