{"created":"2023-05-15T14:34:03.178743+00:00","id":44130,"links":{},"metadata":{"_buckets":{"deposit":"d8da4966-36c4-48c0-b824-907f533d749f"},"_deposit":{"created_by":1,"id":"44130","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44130"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044130","sets":["1"]},"author_link":["438625","438632","438626","438624","438623","438631","438627","438630","438629","438628"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"358","bibliographicPageStart":"353","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"In Vivo"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The rat model of radiation-induced carcinogenesis is widely used to estimate breast cancer risk, but it is unknown whether mammary terminal end buds (TEBs), the hypothesized target of chemical carcinogens, are also targets of radiation-induced carcinogenesis.\nMaterials and Methods: Female Sprague-Dawley rats were irradiated with X-rays (2 Gy). The morphology, bromodeoxyuridine (BrdU)-labeling index and pyknotic index of mammary ductal termini were investigated from 6 hours to 8 weeks post-irradiation. \nResults: Irradiated rats showed a significantly smaller decrease in TEB numbers than controls 4 weeks after irradiation. The BrdU-labeling and pyknotic indexes initially decreased and increased, respectively, recovered to control levels by 3 days post-irradiation, and remained significantly higher until 8 weeks and at 4 weeks post-irradiation, respectively. One case of ductal hyperplasia was observed at 8 weeks. \nConclusions: Irradiation resulted in a persistent proliferation of TEBs, which may be associated with neoplastic transformation via a temporal differentiation arrest.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0258-851X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"438623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"438624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"438625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"438626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"438627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 由希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438632","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-31"},"publish_date":"2006-05-31","publish_status":"0","recid":"44130","relation_version_is_last":true,"title":["Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:03.115290+00:00"}