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In Vitro and in Vivo Comparison of Binding of 99m-Tc-labeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26
https://repo.qst.go.jp/records/44086
https://repo.qst.go.jp/records/44086c3ae09df-2fcf-4ca1-9e5d-f47e39e58a4f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-22 | |||||
| タイトル | ||||||
| タイトル | In Vitro and in Vivo Comparison of Binding of 99m-Tc-labeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Oriuchi, Noboru× Tanada, Shuji× Murata, Hajime× Inoue, Tomio× Sasaki, Yasuhito× et.al× 渡辺 直行× 棚田 修二× 村田 啓× 井上 登美夫× 佐々木 康人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: The purpose of this study was to assess the potential for radioimmunodetection (RAID) of murine anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAb) F33-104 laveled with technetium-99m(99m-Tc) by a reduction-mediated labeling method. Methods: The binding capacity of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA by means of in vitro procedures such as immunoradiometric assay and cell binding assay and the biodistribution of 99m-Tc-labeled anti-CEA MAb F33-104 in normal nude mice and nude mice bearing human colon adenocarcinoma LS180 tumor were investigated and compared with 99m-Tc-labeled anti-CEA MAb BW431/26. Results: The in vitro binding rate of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA in solution and attached to the cell membrane was significantly higher than 99m-Tc-labeled anti-CEA MAb BW431/261 (31.4 0.95% vs. 11.9 0.55% at 100 ng/mL of solube CEA, 83.5 2.84% vs, 54.0 2.54% at 107 of LS 180 cells). In vivo, accumulation of 99m-Tc-labeled anti-CEA MAbF33-104 was higher at 18 h postinjection than 99m-Tc-labeled anti-CEA MAb BW431/26(20.1 3.50% ID/g vs. 14.4 3.30% ID/g). 99m-Tc-activity in the kidneys of nude mice bearing tumor was higher at 18 h postinjection than at 3 h (12.8 2.10% ID/g vs, 8.01 2.40% ID/g of 99m-Tc-labeled anti-CEA MAb F33-104, 10.7 1.70% ID/g vs. 8.10 1.75% ID/g of 99m-Tc-labeled anti-CEA MAb BW431/26). Conclusion: 99m-Tc-labeled anti-CEA MAb F33-104 is a potential novel agent for RAID of recurrent colorectal cancer. | |||||
| 書誌情報 |
Nuklearmedizin 巻 38, p. 115-119, 発行日 1999 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0029-5566 | |||||
