{"created":"2023-05-15T14:34:00.128970+00:00","id":44086,"links":{},"metadata":{"_buckets":{"deposit":"35d55000-a6fd-4f21-b1f8-195faa93e8a5"},"_deposit":{"created_by":1,"id":"44086","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44086"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044086","sets":["1"]},"author_link":["438260","438267","438259","438268","438270","438266","438265","438261","438262","438269","438263","438264"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"119","bibliographicPageStart":"115","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Nuklearmedizin"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: The purpose of this study was to assess the potential for radioimmunodetection (RAID) of murine anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAb) F33-104 laveled with technetium-99m(99m-Tc) by a reduction-mediated labeling method.  Methods: The binding capacity of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA by means of in vitro procedures such as immunoradiometric assay and cell binding assay and the biodistribution of 99m-Tc-labeled anti-CEA MAb F33-104 in normal nude mice and nude mice bearing human colon adenocarcinoma LS180 tumor were investigated and compared with 99m-Tc-labeled anti-CEA MAb BW431/26.  Results: The in vitro binding rate of 99m-Tc-labeled anti-CEA MAb F33-104 with CEA in solution and attached to the cell membrane was significantly higher than 99m-Tc-labeled anti-CEA MAb BW431/261 (31.4 0.95% vs. 11.9 0.55% at 100 ng/mL of solube CEA, 83.5 2.84% vs, 54.0 2.54% at 107 of LS 180 cells). In vivo, accumulation of 99m-Tc-labeled anti-CEA MAbF33-104 was higher at 18 h postinjection than 99m-Tc-labeled anti-CEA MAb BW431/26(20.1 3.50% ID/g vs. 14.4 3.30% ID/g). 99m-Tc-activity in the kidneys of nude mice bearing tumor was higher at 18 h postinjection than at 3 h (12.8 2.10% ID/g vs, 8.01 2.40% ID/g of 99m-Tc-labeled anti-CEA MAb F33-104, 10.7 1.70% ID/g vs. 8.10 1.75% ID/g of 99m-Tc-labeled anti-CEA MAb BW431/26). Conclusion: 99m-Tc-labeled anti-CEA MAb F33-104 is a potential novel agent for RAID of recurrent colorectal cancer.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0029-5566","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"438259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oriuchi, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"438260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanada, Shuji"}],"nameIdentifiers":[{"nameIdentifier":"438261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"438262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Tomio"}],"nameIdentifiers":[{"nameIdentifier":"438263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Yasuhito"}],"nameIdentifiers":[{"nameIdentifier":"438264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"438265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 直行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村田 啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 登美夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 康人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438270","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Vitro and in Vivo Comparison of Binding of 99m-Tc-labeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Vitro and in Vivo Comparison of Binding of 99m-Tc-labeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-22"},"publish_date":"2006-05-22","publish_status":"0","recid":"44086","relation_version_is_last":true,"title":["In Vitro and in Vivo Comparison of Binding of 99m-Tc-labeled Anti-CEA MAb F33-104 with 99m-Tc-labeled Anti-CEA MAb BW431/26"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:36.043071+00:00"}