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The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes
https://repo.qst.go.jp/records/44081
https://repo.qst.go.jp/records/44081e8224423-2d5d-4145-afb9-d673ddcc492a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-20 | |||||
| タイトル | ||||||
| タイトル | The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Wakamatsu, Kazumasa× Ito, Shosuke× Kawa, Yoko× Mizoguchi, Masako× et.al× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The slaty (slt) mutation is known to reduce the activity of dopachrome tautomerase (Dct)/tyrosinase (Tyr)-related protein (TRP)-2 in melanocytes. However, it is unknown whether the reduced Dct activity leads to a defect in the proliferation and differentiation of mouse melanocytes. To address this point, the proliferation and differentiation of neonatal melanocytes from congenic mice in serum-free primary culture were investigated in detail. The proliferation of slaty epidermal melanoblasts/melanocytes in culture did not differ from that of wild-type mice. However, the differentiation was greatly inhibited. Tyr activity detected by dopa reaction as well as staining of Dct/TRP-2 in slaty melanocytes was greatly reduced. The content of eumelanin in cultured slaty melanocytes was reduced, whereas the content of pheomelanin in media derived from cultured 7.5-day-old slaty melanocytes was greatly increased. The contents of eumelanin and pheomelanin in the neonatal slaty epidermis and dermis were reduced, except that the pheomelanin content in 3.5-day-old dermis was increased. These results suggest that the slaty gene affects both eumelanin and pheomelanin synthesis in developmental stage-specific and skin site-specific manners, and, in addition, the gene controls the differentiation of melanocytes via the regulation of activities of Dct/TRP-2 and Tyr. | |||||
| 書誌情報 |
European Journal of Cell Biology 巻 85, 号 6, p. 537-549, 発行日 2006-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0171-9335 | |||||
