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Yttrium-90-Labeled Human Macroaggregated Albumin for Internal Radiotherapy: Combined Use with DTPA
https://repo.qst.go.jp/records/44065
https://repo.qst.go.jp/records/44065db8ad6f7-8561-4fbe-9a44-27c7111c4e5b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-09 | |||||
| タイトル | ||||||
| タイトル | Yttrium-90-Labeled Human Macroaggregated Albumin for Internal Radiotherapy: Combined Use with DTPA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Oriuchi, Noboru× Endou, Keigo× Inoue, Tomio× Tanada, Shuji× Murata, Hajime× Sasaki, Yasuhito× 渡辺 直行× 遠藤 啓吾× 井上 登美夫× 棚田 修二× 村田 啓× 佐々木 康人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study was to investigate the possibility of yttrium-90-labeled human macroaggregated albumin (90Y-MAA)as an internal radiotherapeutic agent for whole-lung irradiation in combination with diethylenetriamine pentaacetic acid (DTPA). The influence of trisodium calcium DTPA (CaNa3DTPA) on the radioactivity of 90Y-MAA in serum wa investigated in vitro. The effect of CaNa3DTPA on the biodistribution of radioactivity in normal mice intraveneously injected with 90Y-MAA was examined. CaNa3DTPA could deprive in vitro radioactivity of 90Y-MAA in 48-h incubation. Most of the radioactivity (>90% injected dose per lung) was observed at murine lung after injection of 90Y-MAA. Pulmonary radioactivity was cleared within 72 h postinjection, whereas the radioacivities in the bone, liver, kidneys, and spleen increased with a peak at 48 h. CaNa3DTPA-treatment reduced the in vivo radioactivities in bone, liver, and kidneys without influence on the radioactivity of lung. In conclusion, combined use of CaNa3DTPA enables 90Y-MAA to be used as a radiopharmaceutical for internal irradiation against whole lung. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 26, 号 7, p. 847-851, 発行日 1999 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
