{"created":"2023-05-15T14:33:58.682661+00:00","id":44065,"links":{},"metadata":{"_buckets":{"deposit":"3b262049-ca5b-48d0-a37f-6a7a1e149b18"},"_deposit":{"created_by":1,"id":"44065","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44065"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044065","sets":["1"]},"author_link":["437989","437994","437985","437986","437991","437995","437984","437990","437988","437983","437993","437987","437992"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"851","bibliographicPageStart":"847","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the possibility of yttrium-90-labeled human macroaggregated albumin (90Y-MAA)as an internal radiotherapeutic agent for whole-lung irradiation in combination with diethylenetriamine pentaacetic acid (DTPA).  The influence of trisodium calcium DTPA (CaNa3DTPA) on the radioactivity of 90Y-MAA in serum wa investigated in vitro.  The effect of CaNa3DTPA on the biodistribution of radioactivity in normal mice intraveneously injected with 90Y-MAA was examined. CaNa3DTPA could deprive in vitro radioactivity of 90Y-MAA in 48-h incubation. Most of the radioactivity (>90% injected dose per lung) was observed at murine lung after injection of 90Y-MAA.  Pulmonary radioactivity was cleared within 72 h postinjection, whereas the radioacivities in the bone, liver, kidneys, and spleen increased with a peak at 48 h. CaNa3DTPA-treatment reduced the in vivo radioactivities in bone, liver, and kidneys without influence on the radioactivity of lung.  In conclusion, combined use of CaNa3DTPA enables 90Y-MAA to be used as a radiopharmaceutical for internal irradiation against whole lung.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"437983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oriuchi, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"437984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endou, Keigo"}],"nameIdentifiers":[{"nameIdentifier":"437985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Tomio"}],"nameIdentifiers":[{"nameIdentifier":"437986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanada, Shuji"}],"nameIdentifiers":[{"nameIdentifier":"437987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"437988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Yasuhito"}],"nameIdentifiers":[{"nameIdentifier":"437989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 直行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤 啓吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 登美夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村田 啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 康人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437995","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Yttrium-90-Labeled Human Macroaggregated Albumin for Internal Radiotherapy: Combined Use with DTPA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Yttrium-90-Labeled Human Macroaggregated Albumin for Internal Radiotherapy: Combined Use with DTPA"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-09"},"publish_date":"2006-05-09","publish_status":"0","recid":"44065","relation_version_is_last":true,"title":["Yttrium-90-Labeled Human Macroaggregated Albumin for Internal Radiotherapy: Combined Use with DTPA"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:50.507945+00:00"}