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Neural damage due to temporal lobe epilepsy: Dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study
https://repo.qst.go.jp/records/44021
https://repo.qst.go.jp/records/44021f284be95-cd91-45b3-9791-ae3dc85192cf
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-03-16 | |||||
| タイトル | ||||||
| タイトル | Neural damage due to temporal lobe epilepsy: Dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Obata, Takayuki
× Obata, Takayuki× Yasuhiro, Someya× Suhara, Tetsuya× Ikehira, Hiroo× Tanada, Shuji× Okubo, Yoshiro× et.al× 小畠 隆行× 須原 哲也× 池平 博夫× 棚田 修二× 大久保 善朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study was to evaluate the usefulness of proton and phosphorus (1H and 31P) magnetic resonance spectroscopy (MRS) for temporal lobe epilepsy (TLE) patients, and to evaluate neural damage and metabolite dysfunction in the TLE patient brain. We performed 1H and 31P MRS of medial temporal lobes (MTL) in the same TLE patients (n = 14) with a relatively wide range of severity from almost seizure-free to intractable, and calculated the ratio of N-acetylasparate to choline-containing compounds and creatine + phosphocreatine (NAA/Cho + Cr) in 1H MRS and inorganic phosphate to all main peaks (%Pi) in 31P MRS. There was no significant correlation between NAA/(Cho + Cr) and %Pi in each side (ipsilateral, r = -0.20; contralateral, r = -0.19). The values of NAA/(Cho + Cr) showed a significant difference between ipsilateral and contralateral MTLs to the focus of TLE patients (P < 0.01, paired t-test). Although %Pi also had a tendency to show the laterality of TLE, there was no significance. Ipsilateral (r = -0.90, P < 0.0001) and contralateral (r = -0.70, P < 0.005) NAA/(Cho + Cr) decreases and contralateral %Pi increase (r = 0.81, P < 0.001) had significant correlation with seizure frequency. There was no significant correlation between NAA/(Cho + Cr) and %Pi. 1H MRS provides more important information concerning neuronal dysfunction in MTL of TLE patients than 31P MRS. | |||||
| 書誌情報 |
Psychiatry and Clinical Neurosciences 巻 58, 号 1, p. 48-53, 発行日 2004-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1323-1316 | |||||
