@article{oai:repo.qst.go.jp:00044021,
 author = {Obata, Takayuki and Yasuhiro, Someya and Suhara, Tetsuya and Ikehira, Hiroo and Tanada, Shuji and Okubo, Yoshiro and et.al and 小畠 隆行 and 須原 哲也 and 池平 博夫 and 棚田 修二 and 大久保 善朗},
 issue = {1},
 journal = {Psychiatry and Clinical Neurosciences},
 month = {Feb},
 note = {The aim of this study was to evaluate the usefulness of proton and phosphorus (1H and 31P) magnetic resonance spectroscopy (MRS) for temporal lobe epilepsy (TLE) patients, and to evaluate neural damage and metabolite dysfunction in the TLE patient brain. We performed 1H and 31P MRS of medial temporal lobes (MTL) in the same TLE patients (n = 14) with a relatively wide range of severity from almost seizure-free to intractable, and calculated the ratio of N-acetylasparate to choline-containing compounds and creatine + phosphocreatine (NAA/Cho + Cr) in 1H MRS and inorganic phosphate to all main peaks (%Pi) in 31P MRS. There was no significant correlation between NAA/(Cho + Cr) and %Pi in each side (ipsilateral, r = -0.20; contralateral, r = -0.19). The values of NAA/(Cho + Cr) showed a significant difference between ipsilateral and contralateral MTLs to the focus of TLE patients (P < 0.01, paired t-test). Although %Pi also had a tendency to show the laterality of TLE, there was no significance. Ipsilateral (r = -0.90, P < 0.0001) and contralateral (r = -0.70, P < 0.005) NAA/(Cho + Cr) decreases and contralateral %Pi increase (r = 0.81, P < 0.001) had significant correlation with seizure frequency. There was no significant correlation between NAA/(Cho + Cr) and %Pi. 1H MRS provides more important information concerning neuronal dysfunction in MTL of TLE patients than 31P MRS.},
 pages = {48--53},
 title = {Neural damage due to temporal lobe epilepsy: Dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study},
 volume = {58},
 year = {2004}
}