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Induction of radical scavenging ability and suppression of lipid peroxidation in rat liver microsomes following whole-body, low-dose X-irradiation
https://repo.qst.go.jp/records/43987
https://repo.qst.go.jp/records/439875e0e6ce3-6012-46a9-8d61-150145060df2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-02-13 | |||||
| タイトル | ||||||
| タイトル | Induction of radical scavenging ability and suppression of lipid peroxidation in rat liver microsomes following whole-body, low-dose X-irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yukawa, Osami
× Yukawa, Osami× Nakajima, Tetsuo× Miura, Yuri× Ueda, Junichi× Ozawa, Toshihiko× 湯川 修身× 中島 徹夫× 上田 順市× 小澤 俊彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim was to investigate changes in radical scavenging ability and lipid peroxidation in liver microsomal membranes and cooperative of lipid peroxidation by microsomal and cytosolic radical scavengers, 24h after whole-body, low-dose X-irradiation of rats. Male Wistar rats were irradiated with 1-50 cGy of X-rays. Liver microsomal radical scavenging ability was determined using the trapping ability of DPPH, a stable free radical. Microsomal alpha-tocopherol (VitE) content was determined using an electrochemical detector. Microsomal glutathione peroxidase (GPX) activity was determined as the consuming rate of NADPH. Microsomal lipid peroxidation was determined by the thiobarbituric acid method. Low molecular weight radical scavenging ability, including alpha-tocopherol, in rat liver microsomes increased 24 h after whole-body, low-dose X-irradiation, showing a maximum level at 5-10 cGy. Microsomal GPX activity also increased 24 h after 5 cGy irradiation. The lipid peroxidation level in microsomes decreased, showing a maximal suppression at 5 cGy. High-dose irradiation-induced microsomal lipid peroxidation was strongly suppressed cooperatively by microsomal and cytosolic antioxidants induced by low-dose irradiation. Low doses of radiation induce increases in liver microsomal antioxidants, which in turn result in enhancing suppressive ability against microsomal lipid peroxidation cooperatively with cytosolic antioxidants induced by low-dose irradiation. | |||||
| 書誌情報 |
International Journal of Radiation Biology 巻 81, 号 9, p. 681-688, 発行日 2005-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
