@article{oai:repo.qst.go.jp:00043987,
 author = {Yukawa, Osami and Nakajima, Tetsuo and Miura, Yuri and Ueda, Junichi and Ozawa, Toshihiko and 湯川 修身 and 中島 徹夫 and 上田 順市 and 小澤 俊彦},
 issue = {9},
 journal = {International Journal of Radiation Biology},
 month = {Sep},
 note = {The aim was to investigate changes in radical scavenging ability and lipid peroxidation in liver microsomal membranes and cooperative of lipid peroxidation by microsomal and cytosolic radical scavengers, 24h after whole-body, low-dose X-irradiation of rats. Male Wistar rats were irradiated with 1-50 cGy of X-rays. Liver microsomal radical scavenging ability was determined using the trapping ability of DPPH, a stable free radical. Microsomal alpha-tocopherol (VitE) content was determined using an electrochemical detector. Microsomal glutathione peroxidase (GPX) activity was determined as the consuming rate of NADPH. Microsomal lipid peroxidation was determined by the thiobarbituric acid method. Low molecular weight radical scavenging ability, including alpha-tocopherol, in rat liver microsomes increased 24 h after whole-body, low-dose X-irradiation, showing a maximum level at 5-10 cGy. Microsomal GPX activity also increased 24 h after 5 cGy irradiation. The lipid peroxidation level in microsomes decreased, showing a maximal suppression at 5 cGy. High-dose irradiation-induced microsomal lipid peroxidation was strongly suppressed cooperatively by microsomal and cytosolic antioxidants induced by low-dose irradiation. Low doses of radiation induce increases in liver microsomal antioxidants, which in turn result in enhancing suppressive ability against microsomal lipid peroxidation cooperatively with cytosolic antioxidants induced by low-dose irradiation.},
 pages = {681--688},
 title = {Induction of radical scavenging ability and suppression of lipid peroxidation in rat liver microsomes following whole-body, low-dose X-irradiation},
 volume = {81},
 year = {2005}
}