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アイテム
Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomas
https://repo.qst.go.jp/records/43957
https://repo.qst.go.jp/records/43957c751e5cd-9160-4a32-b40a-ea1fa8b563e2
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-06 | |||||
| タイトル | ||||||
| タイトル | Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kamada, Tadashi
× Kamada, Tadashi× Tsujii, Hirohiko× Tsuji, Hiroshi× Yanagi, Takeshi× Mizoe, Junetsu× Miyamoto, Tadaaki× Katou, Hirotoshi× Yamada, Shigeru× Morita, Shinroku× Yoshikawa, Kyosan× Kandatsu, Susumu× Tateishi, Akio× 鎌田 正× 辻井 博彦× 辻 比呂志× 柳 剛× 溝江 純悦× 宮本 忠昭× 加藤 博敏× 山田 滋× 森田 新六× 吉川 京燦× 神立 進 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with unresectable bone and soft tissue sarcomas. \nPATIENTS AND METHODS: We conducted a phase I/II dose escalation study of carbon ion radiotherapy. Fifty-seven patients with 64 sites of bone and soft tissue sarcomas not suited for resection received carbon ion radiotherapy. Tumors involved the spine or paraspinous soft tissues in 19 patients, pelvis in 32 patients, and extremities in six patients. The total dose ranged from 52.8 to 73.6 gray equivalent (GyE) and was administered in 16 fixed fractions over 4 weeks (3.3 to 4.6 GyE/fraction). The median tumor size was 559 cm3 (range, 20 to 2,290 cm3). The minimum follow-up was 18 months. \nRESULTS: Seven of 17 patients treated with the highest total dose of 73.6 GyE experienced Radiation Therapy Oncology Group grade 3 acute skin reactions. Dose escalation was then halted at this level. No other severe acute reactions (grade > 3) were observed in this series. The overall local control rates were 88% and 73% at 1 year and 3 years of follow-up, respectively. The median survival time was 31 months (range, 2 to 60 months), and the 1- and 3-year overall survival rates were 82% and 46%, respectively. \nCONCLUSION: Carbon ion radiotherapy seems to be a safe and effective modality in the management of bone and soft tissue sarcomas not eligible for surgical resection, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 書誌情報 |
Journal of Clinical Oncology 巻 20, p. 4466-4471, 発行日 2002-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0732-183X | |||||
