@article{oai:repo.qst.go.jp:00043957,
 author = {Kamada, Tadashi and Tsujii, Hirohiko and Tsuji, Hiroshi and Yanagi, Takeshi and Mizoe, Junetsu and Miyamoto, Tadaaki and Katou, Hirotoshi and Yamada, Shigeru and Morita, Shinroku and Yoshikawa, Kyosan and Kandatsu, Susumu and Tateishi, Akio and 鎌田 正 and 辻井 博彦 and 辻 比呂志 and 柳 剛 and 溝江 純悦 and 宮本 忠昭 and 加藤 博敏 and 山田 滋 and 森田 新六 and 吉川 京燦 and 神立 進},
 journal = {Journal of Clinical Oncology},
 month = {Nov},
 note = {PURPOSE: To evaluate the tolerance for and effectiveness of carbon ion
radiotherapy in patients with unresectable bone and soft tissue sarcomas.
\nPATIENTS AND METHODS: We conducted a phase I/II dose escalation study of
carbon ion radiotherapy. Fifty-seven patients with 64 sites of bone and soft
tissue sarcomas not suited for resection received carbon ion radiotherapy.
Tumors involved the spine or paraspinous soft tissues in 19 patients, pelvis
in 32 patients, and extremities in six patients. The total dose ranged from
52.8 to 73.6 gray equivalent (GyE) and was administered in 16 fixed
fractions over 4 weeks (3.3 to 4.6 GyE/fraction). The median tumor size was
559 cm3 (range, 20 to 2,290 cm3). The minimum follow-up was 18 months.
\nRESULTS: Seven of 17 patients treated with the highest total dose of 73.6
GyE experienced Radiation Therapy Oncology Group grade 3 acute skin
reactions. Dose escalation was then halted at this level. No other severe
acute reactions (grade > 3) were observed in this series. The overall local
control rates were 88% and 73% at 1 year and 3 years of follow-up,
respectively. The median survival time was 31 months (range, 2 to 60
months), and the 1- and 3-year overall survival rates were 82% and 46%,
respectively.
\nCONCLUSION: Carbon ion radiotherapy seems to be a safe and effective
modality in the management of bone and soft tissue sarcomas not eligible for
surgical resection, providing good local control and offering a survival
advantage without unacceptable morbidity.},
 pages = {4466--4471},
 title = {Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomas},
 volume = {20},
 year = {2002}
}