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DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers
https://repo.qst.go.jp/records/43953
https://repo.qst.go.jp/records/439539b8015a3-ad2c-4e1e-9876-5a522f2ae80f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-05 | |||||
| タイトル | ||||||
| タイトル | DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Gotou, Miyako× Noda, Shuhei× Sagara, Masashi× Yamada, Shigeru× Yamamoto, Naohito× Kawakami, Yoshihiro× Matsui, Yoshifumi× Miyazawa, Yukimasa× Yamazaki, Hideya× Tsuji, Hiroshi× Ohno, Tatsuya× Mizoe, Junetsu× Tsujii, Hirohiko× Imai, Takashi× 岩川 眞由美× 中渡 美也子× 野田 秀平× 相良 雅史× 山田 滋× 山本 尚人× 川上 義弘× 松井 芳文× 宮澤 幸正× 山崎 秀哉× 辻 比呂志× 大野 達也× 溝江 純悦× 辻井 博彦× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We collected peripheral blood (PB) from 556 patients with various types of cancer who had undergone radiotherapy and from 81 healthy volunteers. We exposed whole PB and Epstein-Barr virus-transformed lymphoblastoid cell lines (EBLs) derived from the PB mononucleocytes to X-irradiation (5 Gy). Using the alkaline comet assay, we measured the immediate DNA damage and, at 15 min, the % residual damage. In PB, the immediate damage was similar in patients and healthy volunteers while the % residual damage (mean+/-S.D.) was significantly higher in patients with breast (54.3+/-A23.9), cervical (54.7+/-A23.9), head/neck (56.8+/-A24.4), lung (60.1+/-23.5), or esophageal cancers (59.5+/-A33.7) than in healthy donors (42.9+/-19.6) (P<0.05). We did not observe such differences in the EBV-transformed cell lines. Thus, radiation sensitivity of fresh PB cells measured by the alkaline comet assay was related to cancer status. | |||||
| 書誌情報 |
Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research 巻 588, p. 1-6, 発行日 2005-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1383-5718 | |||||
