@article{oai:repo.qst.go.jp:00043953,
 author = {Iwakawa, Mayumi and Gotou, Miyako and Noda, Shuhei and Sagara, Masashi and Yamada, Shigeru and Yamamoto, Naohito and Kawakami, Yoshihiro and Matsui, Yoshifumi and Miyazawa, Yukimasa and Yamazaki, Hideya and Tsuji, Hiroshi and Ohno, Tatsuya and Mizoe, Junetsu and Tsujii, Hirohiko and Imai, Takashi and 岩川 眞由美 and 中渡 美也子 and 野田 秀平 and 相良 雅史 and 山田 滋 and 山本 尚人 and 川上 義弘 and 松井 芳文 and 宮澤 幸正 and 山崎 秀哉 and 辻 比呂志 and 大野 達也 and 溝江 純悦 and 辻井 博彦 and 今井 高志},
 journal = {Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research},
 month = {Dec},
 note = {We collected peripheral blood (PB) from 556 patients with various types of cancer who had undergone radiotherapy and from 81 healthy volunteers. We exposed whole PB and Epstein-Barr virus-transformed lymphoblastoid cell lines (EBLs) derived from the PB mononucleocytes to X-irradiation (5 Gy). Using the alkaline comet assay, we measured the immediate DNA damage and, at 15 min, the % residual damage. In PB, the immediate damage was similar in patients and healthy volunteers while the % residual damage (mean+/-S.D.) was significantly higher in patients with breast (54.3+/-A23.9), cervical (54.7+/-A23.9), head/neck (56.8+/-A24.4), lung (60.1+/-23.5), or esophageal cancers (59.5+/-A33.7) than in healthy donors (42.9+/-19.6) (P<0.05). We did not observe such differences in the EBV-transformed cell lines. Thus, radiation sensitivity of fresh PB cells measured by the alkaline comet assay was related to cancer status.},
 pages = {1--6},
 title = {DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers},
 volume = {588},
 year = {2005}
}