WEKO3
アイテム
Histological and elemental changes in the rat brain after local irradiation with carbon ion beams
https://repo.qst.go.jp/records/43886
https://repo.qst.go.jp/records/438864c3de031-d912-4028-b243-dbd33c35f731
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-15 | |||||
| タイトル | ||||||
| タイトル | Histological and elemental changes in the rat brain after local irradiation with carbon ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Sentaro
× Takahashi, Sentaro× Xue, Zhi Sun× Kubota, Yoshihisa× Takai, Nobuhiko× Nojima, Kumie× 高橋 千太郎× 孫 学智× 久保田 善久× 高井 伸彦× 野島 久美恵 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The left cerebral hemispheres of adult Sprague-Dawley rat brains were irradiated at doses of 30, 50, or 100 Gy with changed carbon particles (290 MeV/nucleon; 5 mm spread-out Bragg peak). The spread-out Bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. A histological examination showed that necrotic tissue damage, hemorrhage in the thalamus, and vasodilatations around the necrotic region were induced at 8 weeks after 100 Gy irradiation. The regions with tissue damage correlated well with those expected from the radiation-dose distribution, indicating an advantage of charged carbon particles for irradiating restricted brain regions. An X-ray fluorescent analysis demonstrated a decrease in the concentrations of K and P, and an increase in the concentrations of Cl, Fe, Zn in the damaged region at 8 weeks post-irradiation, though no significant changes were observed before 4 weeks of post-irradiation. This may indicate that even the very high radiation doses used here did not induce acute and immediate neuronal cell death, in contrast with ischemic brain injury were acute neuronal cell death occurred and the elemental concentrations changed within a day after the induction of ischemia. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 43, p. 143-152, 発行日 2002 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
