@article{oai:repo.qst.go.jp:00043886,
 author = {Takahashi, Sentaro and Xue, Zhi Sun and Kubota, Yoshihisa and Takai, Nobuhiko and Nojima, Kumie and 高橋 千太郎 and 孫 学智 and 久保田 善久 and 高井 伸彦 and 野島 久美恵},
 journal = {Journal of Radiation Research},
 month = {},
 note = {The left cerebral hemispheres of adult Sprague-Dawley rat brains were irradiated at doses of 30, 50, or 100 Gy with changed carbon particles (290 MeV/nucleon; 5 mm spread-out Bragg peak). The spread-out Bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. A histological examination showed that necrotic tissue damage, hemorrhage in the thalamus, and vasodilatations around the necrotic region were induced at 8 weeks after 100 Gy irradiation. The regions with tissue damage correlated well with those expected from the radiation-dose distribution, indicating an advantage of charged carbon particles for irradiating restricted brain regions. An X-ray fluorescent analysis demonstrated a decrease in the concentrations of K and P, and an increase in the concentrations of Cl, Fe, Zn in the damaged region at 8 weeks post-irradiation, though no significant changes were observed before 4 weeks of post-irradiation. This may indicate that even the very high radiation doses used here did not induce acute and immediate neuronal cell death, in contrast with ischemic brain injury were acute neuronal cell death occurred and the elemental concentrations changed within a day after the induction of ischemia.},
 pages = {143--152},
 title = {Histological and elemental changes in the rat brain after local irradiation with carbon ion beams},
 volume = {43},
 year = {2002}
}