WEKO3
アイテム
Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis
https://repo.qst.go.jp/records/43860
https://repo.qst.go.jp/records/43860fe74c74b-4543-43a0-94c2-108a9999f851
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-05 | |||||
| タイトル | ||||||
| タイトル | Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishii, Hideshi
× Ishii, Hideshi× Inageta, Taeko× Mimori, Koshi× Saito, Toshiyuki× Sasaki, Hiroki× Isobe, Masaharu× Mori, Masaki× M., Croce Carlo× Huebner, Kay× Ozawa, Keiya× Furukawa, Y× 齋藤 俊行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous to the alternative replication factor C subunits Elg1, Ctf18/Chl12, and Rad24 of budding yeast. FRAG1 was identified in a search for key caretaker genes involved in the regulation of genomic stability under conditions of replicative stress. In response to stress, Atr participates in the down-regulation of FRAG1 expression, leading to the induction of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein. We propose that the Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. | |||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America 巻 102, 号 27, p. 9655-9660, 発行日 2005-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0027-8424 | |||||
