{"created":"2023-05-15T14:33:48.670024+00:00","id":43860,"links":{},"metadata":{"_buckets":{"deposit":"59fe7f52-bc36-4212-afb0-6a15b44f04ea"},"_deposit":{"created_by":1,"id":"43860","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43860"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043860","sets":["1"]},"author_link":["436067","436057","436065","436063","436058","436068","436059","436060","436062","436061","436064","436066"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"27","bibliographicPageEnd":"9660","bibliographicPageStart":"9655","bibliographicVolumeNumber":"102","bibliographic_titles":[{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous to the alternative replication factor C subunits Elg1, Ctf18/Chl12, and Rad24 of budding yeast. FRAG1 was identified in a search for key caretaker genes involved in the regulation of genomic stability under conditions of replicative stress. In response to stress, Atr participates in the down-regulation of FRAG1 expression, leading to the induction of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein. We propose that the Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-8424","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishii, Hideshi"}],"nameIdentifiers":[{"nameIdentifier":"436057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inageta, Taeko"}],"nameIdentifiers":[{"nameIdentifier":"436058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimori, Koshi"}],"nameIdentifiers":[{"nameIdentifier":"436059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"436060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"436061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isobe, Masaharu"}],"nameIdentifiers":[{"nameIdentifier":"436062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"436063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M., Croce Carlo"}],"nameIdentifiers":[{"nameIdentifier":"436064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Huebner, Kay"}],"nameIdentifiers":[{"nameIdentifier":"436065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Keiya"}],"nameIdentifiers":[{"nameIdentifier":"436066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Y"}],"nameIdentifiers":[{"nameIdentifier":"436067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 俊行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436068","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-12-05"},"publish_date":"2005-12-05","publish_status":"0","recid":"43860","relation_version_is_last":true,"title":["Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:22:12.955978+00:00"}