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Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice
https://repo.qst.go.jp/records/43853
https://repo.qst.go.jp/records/4385326f47864-94e1-4e49-83fb-7cd0283ccbc9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-16 | |||||
| タイトル | ||||||
| タイトル | Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Noda, Shuhei
× Noda, Shuhei× Iwakawa, Mayumi× Oota, Toshie× Iwata, Masaru× Yang, Minfu× Gotou, Miyako× Tanaka, Hiroko× Harada, Yoshinobu× Imai, Takashi× 野田 秀平× 岩川 眞由美× 太田 敏江× 岩田 賢× 中渡 美也子× 田中 裕子× 原田 良信× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | AIM: To gain insights into inter-strain differences in radiosensitivity. METHODS: Mice of inbred strains, A/J, C57BL/6J, and C3H/HeMs, were irradiated at graded doses ranging from 20 to 60 Gy. Skin reaction and leg contraction were observed for a period of 230 days and between 175 and 350 days, respectively. Gene expressions in leg skin tissue were quantified by quantitative RT-PCR assay at 1, 12 and 72 h after 30 Gy irradiation. Mice were locally irradiated by using a Cs-137 source. RESULTS: The three strains showed various degrees of susceptibility to irradiation has evaluated by skin scores. Large inter-strain differences were also detected in the lengths of contraction. Expressions of several genes such as Per3 and Rad51ap1 displayed inter-strain differences. CONCLUSIONS: The continuum model of tissue injury revealed that genetic factor, which varies among strains, is one of the causes of variances in severity of damage after irradiation. | |||||
| 書誌情報 |
Cancer Detection and Prevention 巻 29, 号 4, p. 376-382, 発行日 2005 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0361-090X | |||||
