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Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive 9C-ion beam
https://repo.qst.go.jp/records/43840
https://repo.qst.go.jp/records/4384038c3ed43-7b4a-4f3a-b6e1-f465ab1d809b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-11-04 | |||||
| タイトル | ||||||
| タイトル | Enhanced efficiency in cell killing at the penetration depths around the Bragg peak of a radioactive 9C-ion beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Li, Qiang
× Li, Qiang× Furusawa, Yoshiya× Kanazawa, Mitsutaka× Kanai, Tatsuaki× Kitagawa, Atsushi× Aoki, Mizuho× Urakabe, Eriko× Tomitani, Takehiro× Satou, Shinji× Yoshimoto, Mitsuo× zenkyuan, wei× 李 強× 古澤 佳也× 金澤 光隆× 金井 達明× 北川 敦志× 青木 瑞穂× 新谷 恵理子× 富谷 武浩× 佐藤 眞二× 吉本 光男× 衛 増泉 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the potential importance of radioactive 9C-ion beam in cancer radiotherapy. Methods and Materials: Human salivary gland (HSG) cells were exposed to a double-radiation-source 9C beam at different depths around the Bragg peak. Cell survival fraction was determined by standard clonogenic assay. For comparison, the same experiment was conducted for a therapeutic 12C beam. To determine relative biologic effectiveness (RBE) values, HSG cells were also irradiated with 60Co gamma-rays of fractionation scheme as the reference. Results: The 9C beam was more efficient in cell killing at the depths around its Bragg peak than was the 12C beam, which corresponded to the 9C-ion stopping region and where delayed low-energy particles were emitted. The RBE value at 50% survival level for the 9C beam varied from 1.38 to 4.23. Compared with the 12C beam, the RBE values for the 9C beam were always higher; an increase in RBE by a factor of up to 1.87 has been observed at the depths distal to the Bragg peak. Conclusion: The potential advantage of radioactive 9C-ion beam in cancer therapy has been revealed at low dose rate in comparison with a therapeutic 12C beam. This observation, however, remains to be investigated at therapeutic dose rates in the future. | |||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 63, 号 4, p. 1237-1244, 発行日 2005-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
