WEKO3
アイテム
p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation
https://repo.qst.go.jp/records/43765
https://repo.qst.go.jp/records/437653c2afb1b-9f8b-41a9-8f79-17a49d80bb46
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-08-11 | |||||
| タイトル | ||||||
| タイトル | p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Akihisa
× Takahashi, Akihisa× Ota, I× Tamamoto, Tetsurou× Asakawa, Isao× Nagata, Y× Nakagawa, H× Kondo, N× Ohnishi, Ken× Furusawa, Yoshiya× Matsumoto, Hideki× Oonishi, Takeo× 高橋 昭久× 玉本 哲郎× 浅川 勇雄× 大西 健× 古澤 佳也× 松本 英樹× 大西 武雄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate p53-dependency on combined treatment with radiation and hyperthermia, growth inhibition and apoptosis were analysed using transplantable human tumour. Human head and neck squamous cell carcinoma (HNSCC) cells carrying different p53 genes were transplanted into the thigh of nude mice. When the mean diameter of tumour reached 5-6 mm, the tumours were exposed to X-rays (2 Gy) or Carbon-ion (C-) beams (1 Gy) followed by heating at 42 degrees C for 20 min. Tumour growth inhibition was evaluated by measuring the diameters of tumour. The induction of apoptosis and accumulation of apoptosis-related proteins were also analysed by immunohistochemical staining. Synergistic enhancement of tumour growth inhibition by hyperthermia was observed in wild-type p53 tumours treated with X-rays or C-beams but not in mutant p53 tumours. The incidence of apoptotic cells and activated-caspase-3-positive cells after combined treatment with them were significantly high in wild-type p53 tumours compared with that in mutant p53 tumours. The hyperthermic enhancement of tumour growth inhibition by X-ray- or C-beam-irradiation was p53-dependent, suggesting that it might be highly correlated with p53-dependent apoptosis. | |||||
| 書誌情報 |
International Journal of Hyperthermia 巻 19, 号 2, p. 145-153, 発行日 2003-04 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0265-6736 | |||||
