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Fine Mapping of Radiation Susceptibility and Gene Expression Analysis of LEC Congenic Rat Lines
https://repo.qst.go.jp/records/43763
https://repo.qst.go.jp/records/437635423bd7b-38a2-4a2d-b78e-527009f0e4a7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-08-11 | |||||
| タイトル | ||||||
| タイトル | Fine Mapping of Radiation Susceptibility and Gene Expression Analysis of LEC Congenic Rat Lines | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tsuji, Atsushi
× Tsuji, Atsushi× Sugyou, Aya× Ogiu, Toshiaki× Sagara, Masashi× Suga, Tomo× Ishikawa, Atsuko× Sudou, Hitomi× Ohtuki, Marika× Aburatani, Hiroyuki× Imai, Takashi× Harada, Yoshinobu× 辻 厚至× 須尭 綾× 荻生 俊昭× 相良 雅史× 菅 智× 石川 敦子× 須藤 仁美× 大月 まり香× 今井 高志× 原田 良信 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | LEC rats constitute an animal model of high susceptibility to X-rays. We developed congenic LEC rat lines (recipient strain, Fischer 344 (F344)) and performed genome-wide genotyping to identify radiation susceptibility genes. We mapped seven positional candidate genes, Bmp10, Gpr73, Gp9, Cnbp, Copg, Rab7, and Rpn1, to an approximately 1.2-Mb region located between loci D4Got85 and D4Got148 on chromosome 4. None of the seven genes has been reported to be associated with radiation susceptibility. Comparison of the coding sequences for these seven genes in F344 and LEC rats showed no changes in deduced amino acid sequences. We determined gene expression differences in Gp73, Gp9, and Cnbp as well as strain-specific variations in upstream sequences of these genes. Our results suggest that radiation susceptibility in the LEC rat is primarily attributable to one of the genes within this approximately 1.2-Mb region; however, expression analysis gave no clear indication as to which gene is responsible. | |||||
| 書誌情報 |
Genomics 巻 86, p. 271-279, 発行日 2005-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0888-7543 | |||||
